Glimepiride Pioglitazone and Metformin Hydrochloride(ER) Tablets

Glimepiride, Pioglitazone & Metformin Hydrochloride (ER) Tablets are a triple-combination oral antidiabetic formulation designed for effective management of type 2 diabetes mellitus. This combination works through complementary mechanisms to control blood glucose levels, improve insulin sensitivity, and enhance glycemic control throughout the day.

It is widely prescribed when monotherapy or dual therapy is not sufficient to achieve optimal blood sugar control.

Composition

• Glimepiride
• Pioglitazone
• Metformin Hydrochloride (Extended Release)

Key Benefits

• Provides effective control of blood glucose levels
• Improves insulin sensitivity
• Reduces insulin resistance
• Offers sustained glucose control with ER formulation
• Helps lower fasting and postprandial blood sugar
• Reduces risk of diabetes-related complications

Indications / Uses

• Type 2 Diabetes Mellitus
• Uncontrolled blood sugar with single or dual therapy
• Insulin resistance conditions
• Long-term glycemic management

Mechanism of Action

Glimepiride stimulates insulin release from pancreatic beta cells.
Pioglitazone improves insulin sensitivity in muscle and adipose tissue.
Metformin (ER) reduces hepatic glucose production and improves glucose uptake, providing prolonged glycemic control.

Dosage & Administration

• Take as prescribed by a healthcare professional
• Usually taken once daily with meals
• Swallow whole, do not crush or chew (ER tablet)
• Regular monitoring of blood glucose is advised

Side Effects

• Hypoglycemia (low blood sugar)
• Nausea
• Weight gain
• Edema (fluid retention)
• Diarrhea
• Headache

Precautions

• Monitor blood glucose regularly
• Use cautiously in liver and kidney disorders
• Avoid excessive alcohol intake
• Not recommended in type 1 diabetes
• Consult doctor in pregnancy and lactation

Storage

Store in a cool, dry place away from moisture and sunlight. Keep out of reach of children.

FAQs

What are Glimepiride, Pioglitazone and Metformin ER Tablets used for
This combination is used for the treatment of type 2 diabetes mellitus to control high blood sugar levels.

How does this triple combination work
It works by increasing insulin secretion, improving insulin sensitivity, and reducing glucose production in the liver.

Can this medicine cause low blood sugar
Yes, hypoglycemia may occur, especially if meals are skipped or dosage is high.

Why is Metformin given in extended-release form
Metformin ER provides prolonged action and reduces gastrointestinal side effects.

Can this tablet be taken once daily
Yes, it is usually prescribed once daily, but dosage depends on the doctor’s advice.

Is this combination safe for long-term use
Yes, it can be used long-term under medical supervision with regular monitoring.

Can it cause weight gain
Yes, Pioglitazone may cause mild weight gain in some patients.

Should this tablet be taken before or after food
It is usually recommended to take it with meals to reduce stomach upset.

Can it be used in type 1 diabetes
No, this combination is not suitable for type 1 diabetes.

What precautions should diabetic patients follow while taking this medicine
Patients should monitor blood sugar regularly, follow a proper diet, and maintain an active lifestyle.